Abstract | PURPOSE: MATERIAL AND METHODS: IMT of carotid arteries was measured with B-mode ultrasound in 103 SLE patients and 30 healthy subjects (control group). The presence of AECA was determined with indirect immunofluorescence using human umbilical vein endothelial cells as target. Statistical analysis was performed with chi2 Yates, chi2 Pearson, R Spearman rank test, and logistic multivariate regression analysis. RESULTS: Normal IMT (< or = 0.65 mm) was found in 34 patients. In 52 patients, IMT was 0.66-0.86 mm and in 17 it exceeded 0.86 mm. The difference in comparison with the control group was significant (p = 0.0002). High titers of AECA were significantly more frequent in patients with SLE than in controls (p = 0.0001). In SLE patients, high titers of AECA correlated with IMT greater than 0.86 mm (OR = 6.61; 95% CI: 1.6-28.3). CONCLUSIONS: The presence of antiendothelial cell antibodies is a risk factor for premature, subclinical atherosclerosis in patients with SLE.
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Authors | Katarzyna Fischer, Marek Brzosko, Anna Walecka, Lidia Ostanek, Marcin Sawicki |
Journal | Annales Academiae Medicae Stetinensis
(Ann Acad Med Stetin)
Vol. 52 Suppl 2
Pg. 95-9
( 2006)
ISSN: 1427-440X [Print] Poland |
Vernacular Title | Przeciwciała przeciw komórkom endotelialnym--czynnik ryzyka miazdzycy u chorych na toczeń rumieniowaty układowy. |
PMID | 17471843
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Biomarkers
- anti-endothelial cell antibody
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Topics |
- Adult
- Aged
- Arteriosclerosis
(diagnostic imaging, immunology)
- Autoantibodies
(blood)
- Biomarkers
(blood)
- Carotid Arteries
(diagnostic imaging)
- Cross-Sectional Studies
- Female
- Humans
- Lupus Erythematosus, Systemic
(complications, immunology)
- Male
- Middle Aged
- Multivariate Analysis
- Reference Values
- Risk Factors
- Tunica Intima
(diagnostic imaging, immunology)
- Ultrasonography, Doppler, Duplex
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