[Changes of intercellular spaces of esophageal epithelium in patients with gastroesophageal reflux disease before and after esomeprazole treatment].

Abstract

OBJECTIVE:

To observe the changes of dilated intercellular space (DIS) of esophageal epithelium in different subtypes of gastroesophageal reflux disease (GERD) before and after esomeprazole treatment.

METHODS:

Nineteen patients with GERD, 6 with erosive esophagitis (EE), 7 with NERD with abnormal acid exposure (NERD pH+), and 6 with NERD with normal acid exposure (NERD pH-), were treated with esomeprazole 40 mg daily for two months. During endoscopy before and after treatment, six biopsy specimens were taken from the apparently normal mucosa 3 - 5 cm above the dentate line in the esophagus to undergo HE staining and histological examination and transmission electron microscopy (TEM). Fifteen normal subjects were used as controls.

RESULTS:

Two months after the treatment 5 cases (83.33%) in the EE group, 6 cases (85.57%) in the NERD pH+ group, and 5 cases (83.33%) in the NERD pH- group showed a complete recovery of DIS and complete disappearance of the symptom of heartburn. Two of the left three patients who showed incomplete recovery of DIS still had heartburn.

CONCLUSION:

A complete recovery of DIS 2 months after treatment of esomeprazole is always accompanied by resolution of heartburn symptom. No significant difference in complete recovery of DIS can be found among different GERD subgroups.

• Authors: Jin Tao, Ying-Lian Xiao, Min-Hu Chen, Sui Peng, Jin-Kun Lin, Li-Shou Xiong, Pin-Jin Hu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 87 Issue 6 Pg. 392-5 (Feb 06 2007) ISSN: 0376-2491 [Print] China
• PMID: 17456380 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Ulcer Agents
• Esomeprazole

Topics

• Adult
• Anti-Ulcer Agents (therapeutic use)
• Epithelial Cells (drug effects, pathology, ultrastructure)
• Epithelium (drug effects, pathology, ultrastructure)
• Esomeprazole (therapeutic use)
• Esophagus (drug effects, pathology, ultrastructure)
• Extracellular Space (drug effects)
• Female
• Gastroesophageal Reflux (drug therapy, pathology)
• Humans
• Male
• Matched-Pair Analysis
• Microscopy, Electron, Transmission
• Middle Aged
• Prospective Studies