Daily profile of circulating C-type natriuretic peptide in pre-ascitic cirrhosis and in normal subjects: relationship with renal function.

Abstract

OBJECTIVE:

To investigate whether the C-type natriuretic peptide (CNP) has a role in the regulation of fluid and sodium homeostasis in normal subjects and in pre-ascitic cirrhotic patients.

MATERIAL AND METHODS:

The daily profile of CNP plasma levels was assessed by serial measurements (0700 h, 0900 h, 1800 h, 2300 h) in 10 pre-ascitic cirrhotic outpatients (age 56+/-4 years) and in 10 age-matched healthy controls (54+/-2 years) on a normal sodium diet (150 mmol/day) while carrying on their usual activities (mobile from 0700 h to 2200 h), after an equilibration period of 5 days. Daily diuresis and natriuresis were also monitored.

RESULTS:

Mean daily CNP was comparable in cirrhotic and healthy subjects (3.64+/-0.32 versus 3.20+/-0.20 pg/ml; p=0.139); CNP concentration showed a tendency towards a circadian fluctuation in healthy subjects (p=0.053) but not in patients (p=0.171). Mean daily CNP concentration significantly correlated with 24-h natriuresis (r=0.709; p=0.022) and urine volume (r=0.745; p=0.013) in patients but not in healthy subjects.

CONCLUSIONS:

CNP plasma levels appear to play a role in the water-sodium balance regulation in patients with pre-ascitic cirrhosis.

• Authors: Andrea Zambruni, Franco Trevisani, Veit Gülberg, Paolo Caraceni, Marco Domenicali, Maria Chiara Cantarini, Federica Mirici Cappa, Antonio Di Micoli, Giulia Magini, Antonio Maria Labate-Morselli, Alexander L Gerbes, Mauro Bernardi
• Journal: Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 42 Issue 5 Pg. 642-7 (May 2007) ISSN: 0036-5521 [Print] England
• PMID: 17454886 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Natriuretic Peptide, C-Type

Topics

• Ascites (blood, etiology)
• Circadian Rhythm (physiology)
• Disease Progression
• Follow-Up Studies
• Glomerular Filtration Rate (physiology)
• Humans
• Kidney (physiopathology)
• Liver Cirrhosis (blood, complications)
• Middle Aged
• Natriuresis (physiology)
• Natriuretic Peptide, C-Type (blood)
• Severity of Illness Index