The effects of metabolic syndrome versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events.

Abstract

BACKGROUND:

The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs).

DESIGN, SETTING, AND PATIENTS:

Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease. Metabolic syndrome (MS) score (0-5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. IB score (0-7) was defined as the number of seropositivities to several agents.

RESULTS:

IB score was not associated with plasma C-reactive protein (CRP) concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (P < 0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios 1.51, P < 0.001; and 1.90, P = 0.002, respectively).

CONCLUSION:

Compared with IB, metabolic abnormalities have a more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with coronary artery disease.

• Authors: Dao-Fu Dai, Jou-Wei Lin, Jia-Horng Kao, Chih-Neng Hsu, Fu-Tien Chiang, Jiunn-Lee Lin, Yi-Hua Chou, Kwan-Lih Hsu, Chuen-Den Tseng, Yung-Zu Tseng, Juey-Jen Hwang
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 92 Issue 7 Pg. 2532-7 (Jul 2007) ISSN: 0021-972X [Print] United States
• PMID: 17426096 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• C-Reactive Protein

Topics

• Adult
• Aged
• C-Reactive Protein (metabolism)
• Cohort Studies
• Coronary Artery Disease (epidemiology, immunology)
• Disease-Free Survival
• Female
• Follow-Up Studies
• Humans
• Infections (epidemiology, immunology)
• Inflammation (epidemiology, immunology)
• Male
• Metabolic Syndrome (epidemiology, immunology)
• Middle Aged
• Multivariate Analysis
• Proportional Hazards Models
• Risk Factors
• Severity of Illness Index