Abstract | OBJECTIVE: METHODS: RESULTS: In patients with SLE, erythema of proximal nailfold (P<0.01), splinter haemorrhages in fingernails (P<0.01), capillary loops in proximal nailfold (P<0.05), periungual erythema (P<0.05), and thin nail plates (P<0.05) were more common than those in controls. Only splinter haemorrhages were associated with the disease activity. In patients with SSc and DM/PM, splinter haemorrhages (P<0.05) and capillary loops in proximal nailfold (P<0.01) in fingernails were common as well. Increase in longitudinal curvature (P<0.001), transverse curvature (P<0.01), and white dull colour in fingernails were other frequent findings in patients with SSc. Increase in transverse curvature was associated with the disease activity in SSc. In patients with RA, splinter haemorrhages (P<0.05), red lunula (P<0.05), and white dull colour (P<0.05) in fingernails were frequent. The sensitivity values of all these changes were very low. However, their specificity values were found to be relatively high. CONCLUSION: Proximal nailfold is the most important site of affection in CTDs. These nail changes can be used in combination with highly sensitive diagnostic modalities to establish an accurate diagnosis.
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Authors | S E Tunc, I Ertam, T Pirildar, T Turk, M Ozturk, E Doganavsargil |
Journal | Journal of the European Academy of Dermatology and Venereology : JEADV
(J Eur Acad Dermatol Venereol)
Vol. 21
Issue 4
Pg. 497-503
(Apr 2007)
ISSN: 0926-9959 [Print] England |
PMID | 17373977
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adult
- Arthritis, Rheumatoid
(complications)
- Capillaries
(pathology)
- Case-Control Studies
- Connective Tissue Diseases
(complications, diagnosis)
- Dermatomyositis
(complications)
- Erythema
(etiology)
- Female
- Hemorrhage
(etiology)
- Humans
- Keratosis
(etiology)
- Lupus Erythematosus, Systemic
(complications)
- Male
- Middle Aged
- Nail Diseases
(etiology)
- Nails
(blood supply, pathology)
- Onychomycosis
(complications)
- Pigmentation Disorders
(etiology)
- Polymyositis
(complications)
- Scleroderma, Systemic
(complications)
- Sensitivity and Specificity
- Sjogren's Syndrome
(complications)
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