High oxygen affinity hemoglobin variant in a Canadian family: Hb Bunbury [beta94(FG1)Asp-->Asn, GAC-->AAC].

Abstract

We investigated a three-generation Canadian family in which individuals displayed varying degrees of erythrocytosis due to a high oxygen affinity beta chain hemoglobin (Hb) variant [Hb Bunbury, beta94(FG1)Asp-->Asn, GAC-->AAC]. This is the fourth reported case of Hb Bunbury.

• Authors: Lynda Walker, Barry Eng, Andrew McFarlane, John S Waye
• Journal: Hemoglobin (Hemoglobin) Vol. 31 Issue 1 Pg. 101-3 ( 2007) ISSN: 0363-0269 [Print] England
• PMID: 17365011 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hemoglobins, Abnormal
• Oxyhemoglobins
• hemoglobin Bunbury
• Globins

Topics

• Adult
• Canada
• Female
• Globins (chemistry, genetics)
• Hemoglobins, Abnormal (chemistry, genetics)
• Humans
• Male
• Middle Aged
• Molecular Sequence Data
• Oxyhemoglobins (metabolism)
• Pedigree
• Point Mutation
• Polycythemia (etiology)