[Study on the association between the HLA-DRB1 alleles and type 2 diabetes in Yi nationality of Yunnan].

Abstract

OBJECTIVE:

To investigate the association between the polymorphism of HLA-DRB1 alleles and type 2 diabetes mellitus in Yi nationality of Yunnan.

METHODS:

Polymerase chain reaction-sequence specific primers (PCR-SSP) genotyping method was conducted in 79 patients with type 2 diabetes mellitus and 47 ethnically matched controls in Yi Nationality Autonomous Prefecture, Chuxiong.

RESULTS:

HLA-DR7 and DR11 allele frequencies in type 2 diabetic mellitus patients were significantly higher than those in non-diabetic control subjects respectively(P is 0.009, RR is 8.329;P is 0.029, RR is 7.734).

CONCLUSION:

DR7 and DR11 alleles are probably susceptible genes of type 2 diabetes mellitus in Yunnan Yi nationality.

• Authors: Hong-ying Yang, Li Xue, Mian Xu, Chun-feng Ren, Hui-yun Yuan, Wen-lin Tai, Yu Yang, Wei He
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 24 Issue 1 Pg. 101-3 (Feb 2007) ISSN: 1003-9406 [Print] China
• PMID: 17285557 (Publication Type: English Abstract, Journal Article)

Chemical References

• HLA-DR Antigens
• HLA-DRB1 Chains

Topics

• Adult
• Aged
• Aged, 80 and over
• Alleles
• Base Sequence
• China
• Diabetes Mellitus, Type 2 (genetics)
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• HLA-DR Antigens (genetics)
• HLA-DRB1 Chains
• Humans
• Male
• Middle Aged
• Molecular Sequence Data
• Sequence Analysis, DNA