Development of hepatocellular carcinoma (HCC) in a patient 17 years after recovery from chronic hepatitis B and seroconversion to anti-HBs.

Abstract

A 63-year-old man was admitted to hospital in 2003 for treatment of a hepatocellular carcinoma (HCC). He was negative for HBs antigen (HBsAg) and anti-HCV antibody, and positive for anti-HBs. He had a past history of chronic hepatitis B. In 1986, HBsAg had become negative with the development of anti-HBs. In 2003, an HCC was detected and liver resection was carried out. Histological examination revealed moderately differentiated HCC and slightly fibrotic liver. It is suggested that a diagnosis of HCC, combined with negativity for HBsAg and anti-HCV antibody, may include cases of past recovery from chronic hepatitis B, such as this case.

• Authors: Shuichiro Shigematsu, Teru Kumagi, Yoichi Hiasa, Tomorou Yoshida, Masashi Hirooka, Yoshio Tokumoto, Bunzo Matsuura, Kojiro Michitaka, Norio Horiike, Taiji Tohyama, Morikazu Onji
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 46 Issue 1 Pg. 29-33 ( 2007) ISSN: 1349-7235 [Electronic] Japan
• PMID: 17202730 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Viral

Topics

• Antibodies, Viral (immunology)
• Carcinoma, Hepatocellular (diagnosis, etiology, immunology)
• Disease Susceptibility
• Hepatitis B (immunology)
• Hepatitis B virus (immunology)
• Humans
• Liver (pathology)
• Liver Neoplasms (diagnosis, etiology, immunology)
• Male
• Middle Aged
• Risk Factors