Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma.

Abstract

BACKGROUND:

Tumor protein p53-induced nuclear protein 1 (TP53INP1) is a stress-induced protein and plays a role in cell cycle arrest and p53-mediated apoptosis. In this study, TP53INP1 expression in human breast carcinoma was investigated.

MATERIALS AND METHODS:

TP53INP1 and aberrant p53 expression were investigated immunohistochemically in 81 cases of breast carcinoma.

RESULTS:

Diffuse and intense TP53INP1 expression was observed in the normal mammary gland. Decreased TP53INP1 expression was found in 45 cases (55.6%) of breast carcinoma. The TP53INP1 expression level was inversely linked to tumor size, positive lymph node metastasis, high histological grade and aberrant p53 expression.

CONCLUSION:

Decreased expression of TP53INP1 is involved in breast carcinoma progression.

• Authors: Yasuhiro Ito, Yoshiharu Motoo, Hiroshi Yoshida, Juan Lucio Iovanna, Yuuki Takamura, Akihiro Miya, Kanji Kuma, Akira Miyauchi
• Journal: Anticancer research (Anticancer Res) 2006 Nov-Dec Vol. 26 Issue 6B Pg. 4391-5 ISSN: 0250-7005 [Print] Greece
• PMID: 17201159 (Publication Type: Journal Article)

Chemical References

• Carrier Proteins
• Heat-Shock Proteins
• TP53INP1 protein, human

Topics

• Breast Neoplasms (genetics)
• Carrier Proteins (genetics)
• Female
• Heat-Shock Proteins (genetics)
• Humans
• Immunohistochemistry