Distinct requirements for interleukin-6 in airway inflammation induced by diesel exhaust in mice.

Abstract

To clarify the possible role of interleukin-6 in aggravation of inflammatory responses in diesel exhaust-exposed mice, we compared the infiltration of inflammatory cells and the production of chemokines between interleukin-6-deficient and wild-type mice following 0, 1.0, or 3.0 mg diesel particles/m3 diesel exhaust inhalation for 4 weeks. Exposure to diesel exhaust significantly increased the number of inflammatory cells and the amount of CCL17 and CXCL3 in bronchoalveolar lavage fluids from wild-type mice, but not in interleukin-6-deficient mice. These findings suggest that interleukin-6 plays a critical role in airway inflammatory responses induced by diesel exhaust inhalation.

• Authors: Hidekazu Fujimaki, Yoshika Kurokawa, Shoji Yamamoto, Masahiko Satoh
• Journal: Immunopharmacology and immunotoxicology (Immunopharmacol Immunotoxicol) Vol. 28 Issue 4 Pg. 703-14 ( 2006) ISSN: 0892-3973 [Print] England
• PMID: 17190745 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chemokines
• Chemokines, CXC
• Cxcl3 protein, mouse
• Cytokines
• Interleukin-6
• Vehicle Emissions

Topics

• Animals
• Bronchoalveolar Lavage Fluid (cytology)
• Cells, Cultured
• Chemokines (biosynthesis)
• Chemokines, CXC
• Cytokines (biosynthesis)
• Inflammation (metabolism, pathology)
• Interleukin-6 (genetics, physiology)
• Male
• Mice
• Mice, Knockout
• Respiratory Tract Diseases (pathology)
• Vehicle Emissions (toxicity)