Lafutidine can improve the quality of gastric ulcer healing in humans: a randomized, controlled, multicenter trial.

Abstract

Improving the quality of ulcer healing (QOUH) is one of the valid methods of prevention of relapse of gastric ulcers. We investigated the effect of lafutidine on the QOUH of gastric ulcer compared with famotidine in a randomized, multi-centre controlled trial. Consecutive 80 patients with a gastric ulcer were randomly assigned to receive twice daily either lafutidine (10 mg) or famotidine (20 mg) for 12 weeks. Esophagogastroduodenoscopy was performed to examine the ulcer healing rate and rate of flat type ulcer scars using dye-contrast. The gastric ulcer healing rate was 92.1% in the lafutidine group (35/38) and 94.7% in the famotidine group (36/38). The rate of flat-type ulcer scars was significantly higher in the lafutidine group (68.4%, 26/38) than in the famotidine group (42.1%, 16/38) (P = 0.021). In conclusion, the present study demonstrated that lafutidine, as compared to famotidine, yields a significantly superior QOUH in patients with gastric ulcers in the clinical setting.

• Authors: K Higuchi, T Watanabe, K Tominaga, M Shiba, K Nakagawa, H Uno, K Kitada, H Satoh, S Chono, N Oshitani, Y Fujiwara, T Arakawa
• Journal: Inflammopharmacology (Inflammopharmacology) Vol. 14 Issue 5-6 Pg. 226-30 (Dec 2006) ISSN: 0925-4692 [Print] Switzerland
• PMID: 17186182 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Acetamides
• Anti-Ulcer Agents
• Piperidines
• Pyridines
• lafutidine
• Famotidine

Topics

• Acetamides (administration & dosage, therapeutic use)
• Adult
• Aged
• Anti-Ulcer Agents (administration & dosage, therapeutic use)
• Drug Administration Schedule
• Famotidine (administration & dosage, therapeutic use)
• Female
• Gastroscopy
• Humans
• Male
• Middle Aged
• Piperidines (administration & dosage, therapeutic use)
• Pyridines (administration & dosage, therapeutic use)
• Stomach Ulcer (diagnosis, drug therapy)
• Treatment Outcome
• Wound Healing (drug effects)