Abstract |
Compound 48/80-induced histamine release (HR) from the isolated perfused rat heart was markedly and significantly inhibited by picumast (PIC), possibly by acting as a calmodulin antagonist (CMA) or membrane stabilizer. Trifluoperazine (TFP, another CMA in clinical use) had a similar effect. However, an action as CMA being the basis of inhibition of HR could not be confirmed in another ' allergy' model, namely HR from rat peritoneal mast cells (RPMC). PIC, TFP and two other CMA, W7 and N-(4-aminobutyl)-5-chloro-1- naphthalenesulfonamide) failed consistently to inhibit 48/80-induced HR from RPMC, and when used on their own at high concentration these compounds caused HR. PIC and TFP also potentiated the heat-induced haemolysis of rat erythrocytes, i.e. lacked membrane stabilizing effect in this model.
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Authors | B Y Wan, K H Peh, E S Assem |
Journal | Agents and actions
(Agents Actions)
Vol. 33
Issue 1-2
Pg. 71-5
(May 1991)
ISSN: 0065-4299 [Print] Switzerland |
PMID | 1716840
(Publication Type: Journal Article)
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Chemical References |
- Calmodulin
- Coumarins
- Histamine Antagonists
- picumast
- Trifluoperazine
- p-Methoxy-N-methylphenethylamine
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Topics |
- Animals
- Calmodulin
(antagonists & inhibitors)
- Coumarins
(pharmacology)
- Hemolysis
(drug effects)
- Histamine Antagonists
(pharmacology)
- Histamine Release
(drug effects)
- Hot Temperature
- Male
- Mast Cells
(drug effects, physiology)
- Myocardium
(cytology)
- Peritoneal Cavity
(cytology)
- Rats
- Rats, Inbred Strains
- Trifluoperazine
(pharmacology)
- p-Methoxy-N-methylphenethylamine
(pharmacology)
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