Abstract |
A seventy-five-year-old female with general fatigue, high fever and anemia was admitted. Her chest X-ray film revealed pneumonia. She was diagnosed as RAEB-t with the normal karyotype by peripheral blood film and bone marrow aspiration; 125 micrograms/ml of G-CSF was administered s.c. daily in order to increase neutrophil count because of the prolongation of pneumonia. Her blast cells in both peripheral blood and bone marrow showed a remarkable increase by G-CSF. After the cessation of G-CSF administration, blast cells decreased rapidly, and neutrophil count in the peripheral blood increased. Her pneumonia was then cured. After 5 months of stable hematological state, 60% of her bone marrow cells became occupied by blast cells again. So 2 consecutive courses of 14 days p.o. administration of 1,200 mg MST-16/day were tried. Three months after the first MST-16 trial, her bone marrow showed complete remission (CR) which lasted about 4 months. But she died of sepsis after the first relapse. Her bone marrow in CR still revealed several features of dyspoiesis.
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Authors | T Murate, H Ohashi, Y Kagami, T Hotta, T Murase, Y Hirota, K Kimura |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 18
Issue 12
Pg. 2155-8
(Sep 1991)
ISSN: 0385-0684 [Print] Japan |
PMID | 1716093
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Piperazines
- Granulocyte Colony-Stimulating Factor
- sobuzoxane
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Topics |
- Acute Disease
- Administration, Oral
- Aged
- Anemia, Refractory, with Excess of Blasts
(pathology, therapy)
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Bone Marrow
(pathology)
- Clone Cells
- Female
- Granulocyte Colony-Stimulating Factor
(administration & dosage, therapeutic use)
- Humans
- Leukemia
(drug therapy, pathology)
- Leukocyte Count
- Neutrophils
- Piperazines
(administration & dosage, therapeutic use)
- Remission Induction
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