Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids.

Abstract

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor for cardiovascular disease. In the present study, plasma levels of Lp-PLA(2) were measured in patients (n=301) admitted to elective coronary angiography because of suspected coronary artery disease (CAD). In a multiple linear regression analysis, the degree of CAD (0-, 1-, 2- or 3-vessel disease) and plasma LDL cholesterol significantly correlated to Lp-PLA(2) levels. Also the content of the marine n-3 fatty acid, eicosapentaenoic acid (EPA) in adipose tissue, a measure of long-term intake of seafood independently and inversely (r=-0.18, p<0.01) correlated with plasma levels of Lp-PLA(2). The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease.

• Authors: Erik Berg Schmidt, Wolfgang Koenig, Natalie Khuseyinova, Jeppe Hagstrup Christensen
• Journal: Atherosclerosis (Atherosclerosis) Vol. 196 Issue 1 Pg. 420-424 (Jan 2008) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 17157859 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fatty Acids, Omega-3
• 1-Alkyl-2-acetylglycerophosphocholine Esterase

Topics

• 1-Alkyl-2-acetylglycerophosphocholine Esterase (blood)
• Adipose Tissue (chemistry)
• Aged
• Coronary Artery Disease (blood, physiopathology)
• Denmark
• Fatty Acids, Omega-3 (analysis)
• Female
• Humans
• Linear Models
• Male
• Middle Aged
• Risk Factors
• Seafood