Fatal cerebral haemorrhage after liver transplantation in a patient with transthyretin variant (gly53glu) amyloidosis.

Abstract

Transthyretin (TTR) amyloidosis is a form of systemic amyloidosis caused by an amyloidogenetic TTR variant. The most common mutant forms of TTR are mainly produced by the liver and therefore orthotopic liver transplantation (OLT) is currently accepted as the only known curative treatment. We describe the clinical and pathological features of a patient with TTR variant (gly53glu) with TTR amyloid infiltration of the leptomeningeal vessels in whom fatal cerebral haemorrhage occurred two months after OLT, soon after severe viral pneumonia.

• Authors: P De Carolis, M Galeotti, G Ficarra, M Masetti, D Grimaldi, P Cortelli
• Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 27 Issue 5 Pg. 352-4 (Nov 2006) ISSN: 1590-1874 [Print] Italy
• PMID: 17122946 (Publication Type: Case Reports, Journal Article)

Chemical References

• Prealbumin
• Glutamic Acid
• Glycine

Topics

• Adult
• Amyloidosis (genetics, surgery)
• Cerebral Hemorrhage (etiology)
• Glutamic Acid (genetics)
• Glycine (genetics)
• Humans
• Liver Transplantation (adverse effects)
• Male
• Mutation
• Prealbumin (genetics)