[Expression of estrogen receptor-related receptor alpha and estrogen receptor alpha in endometrial carcinoma and the primary investigation of their clinical significance].

Abstract

OBJECTIVE:

To explore the roles of estrogen receptor-related receptor (ERR) alpha and estrogen receptor alpha in endometrial carcinoma and their clinical values.

METHODS:

Thirty-five cases of endometrial carcinoma were examined by immunohistochemistry. Clinicopathologic features including FIGO stage, histological grade, myometrial invasion and nodal metastasis were reviewed.

RESULTS:

The expression rate of ERalpha in patients with FIGO stage I endometrial carcinoma was more than that in stage II-IV(P = 0.005). The expression rate of ERRalpha in endometrial carcinoma patients at FIGO stage I was lower than that at stages II-IV(P = 0.007). The percentage of patients at FIGO stageI or with G1-2 or myometrial invasion < 1/2 in ERalpha (+) and ERRalpha (-) groups was higher than that in ERalpha (-) and ERRalpha (+) groups(P = 0.000, P = 0.031 and P = 0.022).

CONCLUSION:

ERalpha may be a biomarker of good prognosis while ERRalpha may serve as a biomarker of poor prognosis in endometrial carcinoma. The combinative measure of ERalpha and ERRalpha may improve the prognostic value.

• Authors: Min Gao, Li-hui Wei, Peng-ming Sun, Dan Zhao, Xiao-ping Li
• Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences (Beijing Da Xue Xue Bao Yi Xue Ban) Vol. 38 Issue 5 Pg. 463-5 (Oct 18 2006) ISSN: 1671-167X [Print] China
• PMID: 17068614 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Estrogen Receptor alpha
• Receptors, Estrogen

Topics

• Adenocarcinoma (metabolism, pathology)
• Adult
• Aged
• Biomarkers, Tumor (biosynthesis)
• Endometrial Neoplasms (metabolism, pathology)
• Estrogen Receptor alpha (biosynthesis)
• Female
• Humans
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Staging
• Prognosis
• Receptors, Estrogen (biosynthesis)
• ERRalpha Estrogen-Related Receptor