[Immunogenetic prognosis and long-term results of surgery for gastric cancer].

Abstract

A link between HLA allelic variants and long-term results of surgery for gastric tumors was established on the basis of a 10-years follow-up of 112 cancer patients (stage I-II--37.9, III-IV--62.1%; radical surgery--44.6%). HLA class I was studied in a lymphocytotoxic test; HLA class II--gene DRBI specificity using polymerase chain reaction of peripheral blood cell DNA. The control group included healthy subjects living in the city of Novosibirsk (n = 341). High frequency of antigens HLA-B41, -DR1, -DR7 (p < 0.01) co-occurred with HLA-A2, -B12, -B13 and -B18 presence (p < 0.05) in breast cancer patients. Clinical manifestations of cancer were shown to develop in HLA-A1, -B8, -B15, -DR3 and -DR5 carriers at early stages. Tumor development at later stages (III-IV) was associated with HLA-A2, -B12, -B17, -B35, -B41 and -DR7. A link was registered between lethality rate, on the one hand, and HLA-A3, -B22, and, in particular, DR4, on the other, while remission of more than 7-years--with HLA-A11, -B13, -B21 and -DR5. HLA-B22/DR3 phenotype involved worse prognosis in radically-treated patients whereas that of HLA-B8/DR3--a better one.

• Authors: I Iu Korotkova, D N Egorov, I G Solov'eva, M M Cherenkova, K V Vardosanidze, V V Abramov, V I Konenkov
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 51 Issue 6 Pg. 672-9 ( 2005) ISSN: 0507-3758 [Print] Russia (Federation)
• PMID: 17037033 (Publication Type: English Abstract, Journal Article)

Chemical References

• HLA Antigens

Topics

• Aged
• Cytotoxicity Tests, Immunologic
• Female
• Gene Frequency
• Genes, MHC Class I
• Genes, MHC Class II
• HLA Antigens (genetics)
• Humans
• Male
• Middle Aged
• Phenotype
• Polymerase Chain Reaction
• Predictive Value of Tests
• Prognosis
• Stomach Neoplasms (genetics, immunology, mortality, surgery)
• Time Factors