Administered dose and tumor dose of bleomycin labeled with cobalt-57 in mice and men.

Abstract	Tumor concentrations of the chemotherapeutic drug, bleomycin, labeled with cobalt-57 (Co-bleo) were compared in mouse tumor models and in human lung tumors using quantitative single-photon emission computed tomography. Drug concentrations in histologically similar human tumors showed marked variability for the same injected dose (ID). Small cell carcinomas showed concentrations between 1.09 and 8.85 %ID/cc x 10(-3) while non-small cell lung tumors showed a concentration variation between 0.36 and 6.75 %ID/cc x 10(-3). In contrast to the situation in human tumors, uptake in mouse tumors showed only slight variability in animals with the same tumor model. EMT-6 tumors in mice showed at 6 hr significantly higher uptake of Co-bleo (p less than 0.001) and significantly higher tumor-to-lung ratio (p less than 0.001) when compared to murine fibrosarcomas. The EMT-6 tumors in contrast to the fibrosarcomas responded to bleomycin treatment in a dose dependent manner. The results indicate that while in mice the tumor dose closely follows the administered dose, in humans, the tumor dose and the tumor-to-lung ratio in the individual patient cannot be predicted from the administered dose.
Authors	D Front, O Israel, G Iosilevsky, E Even-Sapir, S Ben-Haim, A Frenkel, R Ber, D Milstein, G M Kolodny
Journal	Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 31 Issue 11 Pg. 1784-90 (Nov 1990) ISSN: 0161-5505 [Print] United States
PMID	1700087 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Cobalt Radioisotopes Bleomycin
Topics	Aged Animals Bleomycin (pharmacokinetics, therapeutic use) Carcinoma, Non-Small-Cell Lung (diagnostic imaging, drug therapy, metabolism) Carcinoma, Small Cell (diagnostic imaging, drug therapy, metabolism) Cobalt Radioisotopes Female Fibrosarcoma (diagnostic imaging, drug therapy, metabolism) Humans Lung Neoplasms (diagnostic imaging, drug therapy, metabolism) Male Mice Middle Aged Sarcoma, Experimental (diagnostic imaging, drug therapy, metabolism) Tissue Distribution Tomography, Emission-Computed, Single-Photon

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