[Expression of E-cadherin and beta-catenin in Bowen's disease and squamous cell carcinoma].

Abstract

OBJECTIVE:

To investigate the involvement of E-cadherin-catenin adhesion system in Bowen's disease (BD) and cutaneous squamous cell carcinoma (SCC).

METHODS:

Fifteen normal skin, 28 BD and 18 SCC specimens were stained with monoclonal antibodies against E-cadherin and beta-catenin. Evaluation of the staining results was performed with semi-quantification of the pattern and intensity of staining, percentage of positive cells, and cytoplasmic staining.

RESULT:

Normal skins strongly expressed membranous E-cadherin and beta-catenin, but their expression was remarkably reduced in BD and SCC. Abnormal staining of beta-catenin was observed in the cytoplasm or cell nuclei of BD and SCC.

CONCLUSION:

Abnormal expression of the E-cadherin/catenin complex is common in SCC and BD.

• Authors: Zheng-xiao Li, Zhen-hui Peng, Fan-pu Ji, Jing-yi Yuan, Min Pan, Yan Liu, Qiong Wang
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 26 Issue 8 Pg. 1245-7 (Aug 2006) ISSN: 1673-4254 [Print] China
• PMID: 16939929 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cadherins
• beta Catenin

Topics

• Adult
• Aged
• Bowen's Disease (metabolism, pathology)
• Cadherins (biosynthesis)
• Carcinoma, Squamous Cell (metabolism, pathology)
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Skin Neoplasms (metabolism, pathology)
• beta Catenin (biosynthesis)