Statins, especially atorvastatin, may improve survival following brachytherapy for clinically localized prostate cancer.

Abstract	This is the largest and longest clinical study to date to examine statin usage and overall patient survival following clinically localized prostate cancer. In a retrospective examination of 938 consecutive patients with early-stage prostate cancer treated with brachytherapy, 191 patients were documented to be taking statin medications. The patients taking statin medications had significantly lower prostate-specific antigen values, percent positive biopsies, and prostate volume than those patients not taking statin medications. Statin usage resulted in a nonstatistical improvement in all survival parameters with the results most pronounced for atorvastatin. Improving prostate cancer survival with statins could have important treatment implications and could potentially limit or even improve the role of supplemental therapies. A prospective trial of statin medications in conjunction with definitive local treatment for prostate cancer is recommended.
Authors	Mark A Moyad, Gregory S Merrick, Wayne M Butler, Kent E Wallner, Robert W Galbreath, Earnest G Butler, Zachariah A Allen, Edward Adamovich
Journal	Urologic nursing (Urol Nurs) Vol. 26 Issue 4 Pg. 298-303 (Aug 2006) ISSN: 1053-816X [Print] United States
PMID	16939047 (Publication Type: Journal Article)
Chemical References	Fatty Acids, Monounsaturated Heptanoic Acids Hydroxymethylglutaryl-CoA Reductase Inhibitors Indoles Pyrroles Fluvastatin Lovastatin Atorvastatin Simvastatin Pravastatin
Topics	Aged Atorvastatin Biopsy Brachytherapy Cause of Death Chemotherapy, Adjuvant Chi-Square Distribution Disease-Free Survival Fatty Acids, Monounsaturated (therapeutic use) Fluvastatin Follow-Up Studies Heptanoic Acids (therapeutic use) Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use) Indoles (therapeutic use) Lovastatin (therapeutic use) Male Neoplasm Staging Pravastatin (therapeutic use) Proportional Hazards Models Prostatic Neoplasms (drug therapy, mortality, pathology, radiotherapy) Pyrroles (therapeutic use) Retrospective Studies Simvastatin (therapeutic use) Survival Analysis

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