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Obstructive jaundice leads to accumulation of oxidized low density lipoprotein in human liver tissue.

Abstract
Oxidized low density lipoprotein (ox-LDL) molecule is one of the most important modified lipoproteins produced during the oxidative stress. Modified lipoproteins have been defined as being part of the immune inflammatory mechanisms in association with oxidant stress. We have reported the accumulation of ox-LDL in Balb/c mice liver after bile duct ligation previously. Here, we investigated this finding in human beings with obstructive jaundice. Our study demonstrates that obstructive jaundice results in tremendous accumulation of ox-LDL in the liver tissue of patients.
AuthorsMustafa Comert, Yucel Ustundag, Ishak Ozel Tekin, Banu Dogan Gun, Figen Barut
JournalWorld journal of gastroenterology (World J Gastroenterol) Vol. 12 Issue 31 Pg. 5094-5 (Aug 21 2006) ISSN: 1007-9327 [Print] United States
PMID16937517 (Publication Type: Letter)
Chemical References
  • Lipoproteins, LDL
  • oxidized low density lipoprotein
Topics
  • Biopsy
  • Gene Expression Regulation
  • Humans
  • Jaundice, Obstructive (pathology)
  • Lipoproteins, LDL (biosynthesis, metabolism)
  • Liver (metabolism)
  • Microscopy, Fluorescence
  • Oxidative Stress

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