Effect of lithium hydroxybutyrate on hemodynamics and respiration in rats with different resistance to hypoxia.

Abstract

Acute experiments on narcotized rats showed that intravenous infusion of GABA derivative lithium hydroxybutyrate induced different changes in hemodynamic and respiratory parameters in animals with high and low resistance to hypoxia. Rats highly resistant to hypoxia better tolerated lithium hydroxybutyrate treatment compared to low resistant animals.

• Authors: N V Sanotskaya, D D Matsievskii, M A Lebedeva
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 141 Issue 1 Pg. 12-6 (Jan 2006) ISSN: 0007-4888 [Print] United States
• PMID: 16929952 (Publication Type: Journal Article)

Chemical References

• Hydroxybutyrates
• Organometallic Compounds
• gamma-Aminobutyric Acid
• lithium hydroxybutyrate

Topics

• Adaptation, Physiological
• Animals
• Drug Tolerance
• Hemodynamics (drug effects)
• Hydroxybutyrates (administration & dosage, chemistry, pharmacology)
• Hypoxia (physiopathology)
• Infusions, Intravenous
• Male
• Organometallic Compounds (administration & dosage, chemistry, pharmacology)
• Rats
• Respiration (drug effects)
• gamma-Aminobutyric Acid (chemistry, metabolism)