Preliminary results of a phase I/II study of sodium pentosanpolysulfate in the treatment of chronic radiation-induced proctitis.

Abstract

This is a report of a phase I/II study of 13 patients treated with sodium pentosanpolysulfate (PPS) for chronic radiation-induced proctitis. A complete response was obtained in 82%, a partial response occurred in 9%, and 9% failed to respond to therapy. No significant toxicity was observed. It is concluded that PPS is an effective treatment for chronic radiation-induced proctitis and a phase III randomized, double-blind study of PPS versus placebo is planned.

• Authors: P W Grigsby, M V Pilepich, C L Parsons
• Journal: American journal of clinical oncology (Am J Clin Oncol) Vol. 13 Issue 1 Pg. 28-31 (Feb 1990) ISSN: 0277-3732 [Print] United States
• PMID: 1689537 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Polysaccharides
• Pentosan Sulfuric Polyester

Topics

• Adult
• Aged
• Aged, 80 and over
• Drug Evaluation
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Pentosan Sulfuric Polyester (administration & dosage, therapeutic use)
• Polysaccharides (therapeutic use)
• Proctitis (drug therapy, etiology)
• Radiation Injuries (drug therapy, etiology)
• Radiotherapy (adverse effects)
• Rectum (radiation effects)
• Recurrence
• Remission Induction