Abstract |
Combination therapy for moderate to severe psoriasis is often used to enhance efficacy and minimize treatment-related side effects; however, data are limited on combination therapy with the newer biologic agents. The current study examined patients who received alefacept in combination with ultraviolet B phototherapy as part of an international, open-label study evaluating up to 3 courses of alefacept in combination with other psoriasis therapies. Physician Global Assessment [corrected] scores improved by [greater than or equal to] 1 category in 88% [corrected] of patients and by [greater than or equal to] 2 categories in 76% [corrected] of patients in course A; [corrected] corresponding response rates were 100% and 55% in Course [corrected] B, and 85% and 77% in Course [corrected] C. At week 14, a PGA of "almost clear" or "clear" was achieved by 13%, 14%, and 8% of patients in courses A, B, and C, respectively. There was no evidence of a cumulative effect on T cells after multiple courses of therapy. The combination of alefacept and ultraviolet B was well tolerated and provided improvement in psoriasis.
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Authors | John Y M Koo, Jerry Bagel, Marianne T Sweetser, Barry S Ticho |
Journal | Journal of drugs in dermatology : JDD
(J Drugs Dermatol)
2006 Jul-Aug
Vol. 5
Issue 7
Pg. 623-8
ISSN: 1545-9616 [Print] United States |
PMID | 16865867
(Publication Type: Controlled Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Recombinant Fusion Proteins
- Alefacept
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Topics |
- Adolescent
- Adult
- Aged
- Alefacept
- CD4 Lymphocyte Count
- Combined Modality Therapy
- Female
- Humans
- Male
- Middle Aged
- Patient Selection
- Psoriasis
(drug therapy, immunology, radiotherapy)
- Recombinant Fusion Proteins
(therapeutic use)
- Safety
- Treatment Outcome
- Ultraviolet Therapy
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