Effects on virological and immunological parameters during CD34 mobilization in HIV patients with lymphoma.

Abstract

The effects of CD34 mobilization with chemotherapy and G-CSF administration were evaluated in 13 HIV-positive patients with relapsed lymphomas and low CD4 counts. After mobilization, CD4+ cells increased significantly while HIV-RNA and integrated HIV-DNA showed no increases. G-CSF led to an increase of CD4+ cells with limited effects on HIV replication.

• Authors: Maria Teresa Bortolin, Cecilia Simonelli, Stefania Zanussi, Chiara Pratesi, Ettore Bidoli, Maurizio Rupolo, Massimiliano Berretta, Rosamaria Tedeschi, Paolo De Paoli
• Journal: American journal of hematology (Am J Hematol) Vol. 81 Issue 10 Pg. 800-2 (Oct 2006) ISSN: 0361-8609 [Print] United States
• PMID: 16838324 (Publication Type: Journal Article)

Chemical References

• Antigens, CD34
• RNA, Viral
• Granulocyte Colony-Stimulating Factor

Topics

• Adult
• Aged
• Antigens, CD34 (drug effects, immunology)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Blood Cell Count
• CD4-CD8 Ratio
• Granulocyte Colony-Stimulating Factor (administration & dosage)
• HIV Infections (complications, immunology, virology)
• Hematopoietic Stem Cell Mobilization
• Humans
• Lymphoma, AIDS-Related (drug therapy, immunology, virology)
• Middle Aged
• Proviruses (drug effects)
• RNA, Viral (analysis, blood)
• Recurrence
• Treatment Outcome
• Virus Replication (drug effects)