[Analysis of death causes of gestational trophoblastic neoplasia patients].

Abstract

OBJECTIVE:

To analyze retrospectively the causes of death in gestational trophoblastic neoplasia (GTN) patients. The prognostic risk factors were also discussed.

METHODS:

One thousand one hundred and thirty GTN patients were hospitalized and treated at Peking Union Medical College Hospital from 1985 to 2004. Sixty-four of them died later and retrospective analyses were carried out on these patients.

RESULTS:

Fifty-eight out of the 64 patients died during initial treatment. The other six died from disease relapse and progression of the disease (PD). The major causes of death were multi-organ failure, intracranial haemorrhage, cerebral herniation, side-effects of chemotherapy, and PD after relapse. The result of multivariate analysis indicated the adverse prognostic factors included the interval between antecedent pregnancy and chemotherapy treatment (OR = 2.857, P < 0.01), the titer of beta subunit of human chorionic gonadotropin (beta-hCG, P < 0.05), the diagnosis of choriocarcinoma (OR = 3.635, P < 0.05), clinical stage (P < 0.05), multiple metastases (OR = 2.201, P < 0.01) and drug resistance (OR = 0.181, P < 0.01).

CONCLUSIONS:

A proper evaluation of a GTN patient before initial treatment is important. More attention should be paid to the death-related prognostic risk factors to improve the prognosis of high risk GTN patients.

• Authors: Jun-jun Yang, Yang Xiang, Xi-run Wan, Qin Li, Feng-quan He, Xiu-yu Yang
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 41 Issue 6 Pg. 403-7 (Jun 2006) ISSN: 0529-567X [Print] China
• PMID: 16831365 (Publication Type: English Abstract, Journal Article)

Topics

• Adult
• Cause of Death
• Female
• Gestational Trophoblastic Disease (complications, mortality, pathology)
• Humans
• Middle Aged
• Multiple Organ Failure (etiology, prevention & control)
• Multivariate Analysis
• Neoplasm Recurrence, Local
• Pregnancy
• Retrospective Studies
• Risk Factors
• Survival Rate