Does a reduction of adhesion molecules by LDL-apheresis have a role in the treatment of sudden hearing loss?

Abstract

Sudden hearing loss (SHL) is a highly disabling affliction that can severely affect the subject's social and relational life. Although the etiology of the complaint is still debated, it is thought that microcirculation disturbances conditioned by an endothelial dysfunction might be the main pathogenetic mechanism. Adhesion molecules favoring interaction between leukocytes and endothelial cells are early markers of endothelial damage. In the present report, we describe a case of SHL that derived evident benefit from a single session of LDL/fibrinogen apheresis, with complete hearing recovery. In this patient, in addition to reducing LDL cholesterol and fibrinogen, the circulating adhesion molecules (sE-selectin, sVCAM-1 and sICAM-1), previously present in higher than normal concentrations, were reduced by the treatment.

• Authors: Alfonso Ramunni, Nicola Quaranta, Maria Teresa Saliani, Rosa Anna Fallacara, Roberto Ria, Giuseppe Ranieri
• Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (Ther Apher Dial) Vol. 10 Issue 3 Pg. 282-6 (Jun 2006) ISSN: 1744-9979 [Print] Australia
• PMID: 16817795 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cell Adhesion Molecules
• Cholesterol, LDL
• Lipoproteins, LDL
• Fibrinogen

Topics

• Blood Component Removal (methods)
• Cell Adhesion Molecules (adverse effects, blood)
• Cholesterol, LDL (blood)
• Female
• Fibrinogen (analysis)
• Hearing Loss, Sudden (etiology, therapy)
• Humans
• Hypercholesterolemia (complications, therapy)
• Lipoproteins, LDL (blood, isolation & purification)
• Middle Aged
• Treatment Outcome