Abstract | PURPOSE: To investigate the effect of topical beta-blockers on the prevalence of depression among glaucoma patients. DESIGN: Retrospective observational population-based cohort study. PARTICIPANTS: We reviewed the electronic medical records of all the members in a district of the largest health maintenance organization in Israel (Central District of Clalit Health Services) who were older than 20 years (317,469 members). METHODS: We documented all antiglaucoma prescriptions (n = 274,023) and all antidepressant prescriptions (n = 16,948) filled by glaucoma patients in the district between January 1, 2001 and December 31, 2003. We included only those patients who filled at least 6 consecutive antiglaucoma prescriptions at least once every 2 months (n = 6597; 5846 [88.6%] were treated with topical beta-blockers). Depressed patients were defined as patients that filled at least four prescriptions for antidepressants during the study period (n= 810, 12.3% of all glaucoma patients). MAIN OUTCOME MEASURE: Relationship of topical beta-blocker use and prevalence of depression among glaucoma patients. RESULTS: No significant demographic differences were noted between glaucoma patients treated and not treated with topical beta-blockers. Of those treated and not treated with beta-blockers, 12.2% (12.7% after age-adjustment) and 12.7%, respectively, were also receiving drug therapy for depression (P = 0.7, chi-square test). With stratification by age, treatment with topical beta-blockers did not influence the prevalence of depression in any age group. Logistic regression analysis revealed a significant effect of age, place of birth, and gender on the prevalence of depression, but the prevalence of use of topical beta-blockers had no significant effect. CONCLUSIONS: Use of topical beta-blockers by glaucoma patients does not appear to increase the risk of depression in this population.
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Authors | Igor Kaiserman, Nadia Kaiserman, Asher Elhayany, Shlomo Vinker |
Journal | Ophthalmology
(Ophthalmology)
Vol. 113
Issue 7
Pg. 1077-80
(Jul 2006)
ISSN: 1549-4713 [Electronic] United States |
PMID | 16815397
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Adrenergic beta-Antagonists
- Antidepressive Agents
- Antihypertensive Agents
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Topics |
- Administration, Topical
- Adrenergic beta-Antagonists
(therapeutic use)
- Aged
- Aged, 80 and over
- Antidepressive Agents
(therapeutic use)
- Antihypertensive Agents
(therapeutic use)
- Chronic Disease
- Depression
(drug therapy, epidemiology)
- Drug Prescriptions
(statistics & numerical data)
- Female
- Glaucoma, Open-Angle
(drug therapy)
- Health Maintenance Organizations
(statistics & numerical data)
- Humans
- Israel
(epidemiology)
- Male
- Middle Aged
- Prevalence
- Retrospective Studies
- Risk Factors
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