BCL10 gene amplification associated with strong nuclear BCL10 expression in a diffuse large B cell lymphoma with IGH-BCL2 fusion.

Abstract

Cytogenetic investigation of a nodal diffuse large B cell lymphoma carrying an IGH-BCL2-fusion revealed a homogeneously staining region at chromosome 1p21-22. Fluorescence in situ hybridisation (FISH) demonstrated heterogeneous BCL10 gene amplification in tumour cells. Immunohistochemistry showed heterogeneous over-expression of the protein in the nuclei of tumour cells, similar to that seen in MALT lymphoma cells with t(1;14)(p22;q32).

• Authors: Hongtao Ye, Stefan Gesk, Jose I Martin-Subero, Alexander Nader, Ming-Qing Du, Reiner Siebert
• Journal: Haematologica (Haematologica) Vol. 91 Issue 6 Suppl Pg. ECR28 (Jun 2006) ISSN: 1592-8721 [Electronic] Italy
• PMID: 16785131 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adaptor Proteins, Signal Transducing
• B-Cell CLL-Lymphoma 10 Protein
• BCL10 protein, human
• FOXP1 protein, human
• Forkhead Transcription Factors
• Immunoglobulin Heavy Chains
• Neoplasm Proteins
• Recombinant Fusion Proteins
• Repressor Proteins
• bcl-2-Associated X Protein
• Caspases
• MALT1 protein, human
• Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein

Topics

• Adaptor Proteins, Signal Transducing (genetics)
• B-Cell CLL-Lymphoma 10 Protein
• Caspases (genetics)
• Chromosome Mapping
• Chromosomes, Human, Pair 1
• Chromosomes, Human, Pair 14
• Forkhead Transcription Factors (genetics)
• Gene Amplification
• Gene Expression Regulation, Neoplastic
• Humans
• Immunoglobulin Heavy Chains (genetics)
• Lymphoma, B-Cell (genetics, pathology)
• Lymphoma, Large B-Cell, Diffuse (genetics, pathology)
• Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
• Neoplasm Proteins (genetics)
• Recombinant Fusion Proteins (genetics)
• Repressor Proteins (genetics)
• Translocation, Genetic
• bcl-2-Associated X Protein (genetics)