Abstract |
Several lines of evidence suggest that metabolic changes in the kynurenic acid (KYNA) pathway are related to the etiology of schizophrenia. The inhibitor of kynurenine 3-monooxygenase (KMO) is known to increase KYNA levels, and the KMO gene is located in the chromosome region associated with schizophrenia, 1q42-q44. Single-marker and haplotype analyses for 6-tag single nucleotide polymorphisms (SNPs) of KMO were performed (cases = 465, controls = 440). Significant association of rs2275163 with schizophrenia was observed by single-marker comparisons (P = 0.032) and haplotype analysis including this SNP (P = 0.0049). Significant association of rs2275163 and haplotype was not replicated using a second, independent set of samples (cases = 480, controls = 448) (P = 0.706 and P = 0.689, respectively). These results suggest that the KMO is unlikely to be related to the development of schizophrenia in Japanese.
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Authors | N Aoyama, N Takahashi, S Saito, N Maeno, R Ishihara, X Ji, H Miura, M Ikeda, T Suzuki, T Kitajima, Y Yamanouchi, Y Kinoshita, K Yoshida, N Iwata, T Inada, N Ozaki |
Journal | Genes, brain, and behavior
(Genes Brain Behav)
Vol. 5
Issue 4
Pg. 364-8
(Jun 2006)
ISSN: 1601-1848 [Print] England |
PMID | 16716206
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Kynurenine 3-Monooxygenase
- Kynurenic Acid
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Topics |
- Aged
- Case-Control Studies
- Chi-Square Distribution
- Chromosomes, Human, Pair 1
(genetics)
- Epigenesis, Genetic
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Japan
- Kynurenic Acid
(metabolism)
- Kynurenine 3-Monooxygenase
(genetics, metabolism)
- Linkage Disequilibrium
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
(genetics)
- Schizophrenia
(genetics)
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