An increase of anticardiolipin antibody in association with stroke and chronic chemical exposure.

Abstract

A chemical worker working with urea-formaldehyde resin hazard for 20 years suffered cerebral ischemia in association with an increase of blood beta2-glycoprotein I-dependent anticardiolipin antibody (aCL)-IgG and IgM isotype, and a prolongation of activated partial thromboplastin time (aPTT). Major histocompatibility complex antigen showed DR4 positivity. On follow-up for over 6 years, aCL-IgG and aPTT decreased to reference range but aCL-IgM was still abnormally high despite a cessation of exposure. This patient highlights the induction of antibody-mediated thrombosis in chronic chemical exposure, especially in an individual with subclinical autoimmune disorder. The role of environment for coagulopathic vascular thrombosis is warranted for investigation.

• Authors: Wei-Hsi Chen, Chun-Chung Lui, Chung-Jen Chen, Jia-Shou Liu
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) Vol. 12 Issue 2 Pg. 231-5 (Apr 2006) ISSN: 1076-0296 [Print] United States
• PMID: 16708128 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Anticardiolipin
• HLA-DR4 Antigen
• Immunoglobulin M
• Formaldehyde
• urea formaldehyde foam
• Urea

Topics

• Adult
• Antibodies, Anticardiolipin (blood)
• Formaldehyde (adverse effects)
• HLA-DR4 Antigen
• Humans
• Immunoglobulin M
• Male
• Occupational Exposure (adverse effects)
• Partial Thromboplastin Time
• Stroke (blood, chemically induced, etiology)
• Thrombosis (etiology)
• Urea (adverse effects)