[A case of gastric cancer presenting with obstructive jaundice and responding to biweekly CPT-11 and CDDP combination administration].

Abstract

A 74-year-old man was suffering from Borrmann type 2 advanced gastric cancer with abdominal lymph node metastases and multiple lung metastases. He started to undergo outpatient treatment with oral administration of TS-1. But pyloric stenosis was found after 6 courses of TS-1 chemotherapy, so he underwent palliative distal gastrectomy. TS-1 chemotherapy was continued afterwards, however obstructive jaundice was found. So combination chemotherapy of CPT-11 60 mg/m(2)and CDDP 30 mg/m(2)biweekly was selected as a second-line therapy after PTCD. As no side effects were found, he could be treated on an outpatient basis by CPT-11 60 mg/body and CDDP 30 mg/body biweekly. Four months has passed since the palliative operation, and the PTCD tube was successfully removed. The abdominal lymph nodes had decreased in size and the patient has maintained good QOL. Thus, combination CPT-11 and CDDP therapy could well be a new candidate for a second-line chemotherapy in outpatients.

• Authors: Toshiro Iizuka, Yoshio Hoshihara, Osamu Hoteya, Takashi Yamamoto, Naohisa Yahagi, Harushi Udagawa
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 33 Issue 5 Pg. 659-61 (May 2006) ISSN: 0385-0684 [Print] Japan
• PMID: 16685167 (Publication Type: Case Reports, Journal Article)

Chemical References

• Irinotecan
• Cisplatin
• Camptothecin

Topics

• Adenocarcinoma, Mucinous (drug therapy, secondary, surgery)
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Drainage
• Drug Administration Schedule
• Gastrectomy
• Humans
• Irinotecan
• Jaundice, Obstructive (drug therapy, etiology, surgery)
• Lymph Node Excision
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Male
• Stomach Neoplasms (drug therapy, pathology, surgery)