Inhibition of putrescine aminopropyltransferase influences rat liver regeneration.

Abstract

A close relationship between rat liver regeneration and the concentration ratio of spermidine to spermine (spd:spm) was demonstrated by the oral administration of trans-4-methylcyclohexylamine (MCHA), a specific inhibitor of putrescine aminopropyltransferase. A decrease in recovery rate of remnant liver with MCHA, as a percentage index of remnant liver weight to body weight, correlated well with a decrease of the spd:spm value, with a correlation coefficient of 0.952 for the remnant livers on day 3 after partial hepatectomy. The decrease in recovery rate could be explained by a prolonged cell cycle based on the data of the proliferating cell nuclear antigen labelling index and mitotic cell index in both livers of day 2 and day 3 after partial hepatectomy. The results presented here will give a new aspect in the field of polyamine regulation to control cell growth in vivo.

• Authors: Masaki Kobayashi, Koichi Takao, Yasuo Shiota, Yoshiaki Sugita, Masakazu Takahashi, Dai Nakae, Keijiro Samejima
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 29 Issue 5 Pg. 863-7 (May 2006) ISSN: 0918-6158 [Print] Japan
• PMID: 16651710 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biogenic Polyamines
• Cyclohexylamines
• Enzyme Inhibitors
• 4-methylcyclohexylamine
• Spermidine Synthase

Topics

• Animals
• Biogenic Polyamines (metabolism)
• Body Weight (drug effects)
• Cell Division (drug effects)
• Cyclohexylamines (pharmacology)
• Enzyme Inhibitors (pharmacology)
• Hepatocytes (drug effects)
• Hydrogen-Ion Concentration
• Immunohistochemistry
• Liver (metabolism)
• Liver Regeneration (drug effects)
• Male
• Mitosis (drug effects)
• Organ Size (drug effects)
• Rats
• Rats, Sprague-Dawley
• Spermidine Synthase (antagonists & inhibitors)