Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy.

Abstract

The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.

• Authors: R Lodi, G Pierangeli, C Tonon, S Cevoli, C Testa, G Bivona, F Magnifico, P Cortelli, P Montagna, B Barbiroli
• Journal: Neurology (Neurology) Vol. 66 Issue 8 Pg. 1264-6 (Apr 25 2006) ISSN: 1526-632X [Electronic] United States
• PMID: 16636250 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Protons
• Aspartic Acid
• N-acetylaspartate
• Creatine

Topics

• Acute Disease
• Adult
• Aged
• Aspartic Acid (analogs & derivatives, antagonists & inhibitors, metabolism)
• Biomarkers (metabolism)
• Cerebral Cortex (metabolism, pathology)
• Chronic Disease
• Cluster Headache (metabolism, pathology)
• Creatine (antagonists & inhibitors, metabolism)
• Female
• Humans
• Hypothalamus (metabolism, pathology)
• Magnetic Resonance Spectroscopy (methods)
• Male
• Middle Aged
• Neurons (metabolism, pathology)
• Occipital Lobe (metabolism, pathology)
• Parietal Lobe (metabolism, pathology)
• Protons