Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population.

Abstract

We examined, for the first time, the possible association between schizophrenia and the anaplastic lymphoma kinase (ALK) gene which plays an important role in neurodevelopment. When two nonsynonymous polymorphisms (Arg1491Lys and Glu1529Asp) were examined, there were significant differences in genotype and allele distributions between patients and controls. Individuals homozygous for the minor allele (1491Lys-1529Asp) were more common in patients than in controls (p = 0.0064, odds ratio 2.4, 95% CI 1.3-4.6). These results suggest that genetic variations of the ALK gene might confer susceptibility to schizophrenia.

• Authors: H Kunugi, R Hashimoto, T Okada, H Hori, T Nakabayashi, A Baba, K Kudo, M Omori, S Takahashi, R Tsukue, K Anami, N Hirabayashi, A Kosuga, M Tatsumi, K Kamijima, T Asada, S Harada, K Arima, O Saitoh
• Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 113 Issue 10 Pg. 1569-73 (Oct 2006) ISSN: 0300-9564 [Print] Austria
• PMID: 16604305 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ALK protein, human
• Anaplastic Lymphoma Kinase
• Protein-Tyrosine Kinases
• Receptor Protein-Tyrosine Kinases

Topics

• Alleles
• Anaplastic Lymphoma Kinase
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Japan (epidemiology)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Single Nucleotide
• Protein-Tyrosine Kinases (genetics)
• Receptor Protein-Tyrosine Kinases
• Schizophrenia (genetics)