P300 auditory event-related potentials and neuropsychological study during donepezil treatment in vascular dementia.

Abstract

After Alzheimer's disease (AD), vascular dementia (VaD) is the most common cause of dementia among the elderly. Abnormalities in neurotransmitter pathways are common pathogenic mechanisms shared by AD and VaD. For one month we studied the effects of donepezil, an acetylcholinesterase inhibitor (5 mg daily), on the cognitive system using P300 auditory event-related potentials (P300) and neuropsychological tests in 10 patients affected by probable VaD according to the NINDS-AIREN criteria. Our data showed a significant improvement of neuropsychological items and P300 latency after one month of donepezil treatment. In conclusion both P300 and neuropsychological tests are indicated in patients with VaD to confirm the efficacy of donepezil treatment during follow-up.

• Authors: C Paci, R Gobbato, T Carboni, S Sanguigni, A Santone, L Curatola
• Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 26 Issue 6 Pg. 435-7 (Feb 2006) ISSN: 1590-1874 [Print] Italy
• PMID: 16601937 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Indans
• Nootropic Agents
• Piperidines
• Donepezil

Topics

• Acoustic Stimulation (methods)
• Aged
• Dementia, Vascular (drug therapy, physiopathology)
• Donepezil
• Electroencephalography (methods)
• Event-Related Potentials, P300 (drug effects)
• Female
• Humans
• Indans (therapeutic use)
• Male
• Middle Aged
• Nootropic Agents (therapeutic use)
• Piperidines (therapeutic use)