Abstract | OBJECTIVE: METHODS: Male rats (n = 34) were cannulated for cardiopulmonary bypass, cooled to a rectal temperature of 16 degrees C to 18 degrees C within 30 minutes, and assigned to deep hypothermic circulatory arrest durations of 0, 45, 60, 75, 90 (n = 6, respectively), or 105 (n = 4) minutes. After rewarming within 40 minutes, animals were weaned from cardiopulmonary bypass at 35.5 degrees C. Neurologic and cognitive performance was assessed with the modified hole board test until postoperative day 14. Thereafter, brains were perfusion fixed and histologically analyzed. RESULTS: Logistic regression analyses identified dose-dependent associations between survival, neurologic or cognitive function, and duration of deep hypothermic circulatory arrest. Functional and histologic deficits were detectable after clinically relevant deep hypothermic circulatory arrest durations. The overall neurologic function did not correlate with histologic outcome (r = 0.51, P > .05). CONCLUSIONS:
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Authors | Bettina Jungwirth, G Burkhard Mackensen, Manfred Blobner, Frauke Neff, Bruno Reichart, Eberhard F Kochs, Georg Nollert |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 131
Issue 4
Pg. 805-12
(Apr 2006)
ISSN: 1097-685X [Electronic] United States |
PMID | 16580438
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Brain
(pathology)
- Cardiopulmonary Bypass
- Cerebellum
(pathology)
- Cognition
- Cognition Disorders
(pathology)
- Disease Models, Animal
- Hippocampus
(pathology)
- Hypothermia, Induced
- Logistic Models
- Male
- Motor Skills
- Purkinje Cells
(pathology)
- Rats
- Rats, Sprague-Dawley
- Time Factors
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