Abstract | PURPOSE OF REVIEW: This review highlights recent advances in understanding the regulation of bile acid transport in cholestasis and in the pathogenesis, outcomes, epidemiology, and treatment of a variety of cholestatic liver diseases and their associated complications. RECENT FINDINGS: SUMMARY: Our understanding of the molecular mechanisms, epidemiology and pathogenesis of cholestasis continues to advance. These advances will hopefully lead to more effective therapies for specific cholestatic conditions.
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Authors | Anna E Rutherford, Daniel S Pratt |
Journal | Current opinion in gastroenterology
(Curr Opin Gastroenterol)
Vol. 22
Issue 3
Pg. 209-14
(May 2006)
ISSN: 0267-1379 [Print] United States |
PMID | 16550034
(Publication Type: Journal Article, Review)
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Chemical References |
- ABCB11 protein, human
- ATP Binding Cassette Transporter, Subfamily B, Member 11
- ATP-Binding Cassette Transporters
- Bile Acids and Salts
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Topics |
- ATP Binding Cassette Transporter, Subfamily B, Member 11
- ATP-Binding Cassette Transporters
(genetics)
- Animals
- Bile Acids and Salts
(metabolism)
- Bile Duct Diseases
(etiology, physiopathology, therapy)
- Biological Transport
(physiology)
- Female
- Humans
- Mutation
- Osteoporosis
(drug therapy, etiology)
- Pregnancy
- Pregnancy Complications
(therapy)
- Pruritus
(drug therapy, etiology)
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