Hepatitis E antibody kinetics in Nepalese patients.

Abstract

A cohort of 62 Nepalese adults with acute hepatitis E was identified and total Ig as well as IgM levels to hepatitis E virus (HEV) capsid protein were determined using the Walter Reed Army Institute of Research (WRAIR) immunoassay. An antibody profile was constructed from serial serum specimens collected up to 14 months following the onset of illness. The decline in total Ig was rapid for the first 3 months. There followed a slow, sustained decline, but antibodies remained above the seropositive level of 20 WRAIR units. The decline of IgM was steeper than total Ig for the first 3 months, but IgM remained detectable after 14 months in 25% of cases. Study data contribute to an understanding of the pathophysiology of human hepatitis E and set an antibody response pattern to be targeted as a part of HEV vaccine development.

• Authors: Khin Saw Aye Myint, Timothy P Endy, Mrigendra P Shrestha, Sanjaya K Shrestha, David W Vaughn, Bruce L Innis, Robert V Gibbons, Robert A Kuschner, Jitvimol Seriwatana, Robert McN Scott
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) Vol. 100 Issue 10 Pg. 938-41 (Oct 2006) ISSN: 0035-9203 [Print] England
• PMID: 16542692 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Capsid Proteins
• Hepatitis Antibodies
• Immunoglobulin G
• Immunoglobulin M

Topics

• Adult
• Capsid Proteins (blood)
• Enzyme-Linked Immunosorbent Assay
• Female
• Hepatitis Antibodies (metabolism)
• Hepatitis E (immunology)
• Hepatitis E virus (immunology)
• Humans
• Immunoglobulin G (metabolism)
• Immunoglobulin M (metabolism)
• Male
• Nepal
• Retrospective Studies