Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019.

Abstract

A new cytotoxic cytochalasan-based alkaloid named chaetoglobosin U (1), along with four known analogues, chaetoglobosins C (2), F (3), and E (5) and penochalasin A (4), has been characterized from the EtOAc extract of a solid culture of Chaetomium globosum IFB-E019, an endophytic fungus residing inside the stem of healthy Imperata cylindrica. The structure of chaetoglobosin U was determined through correlative analyses of its UV, IR, CD, MS, and 1D ((1)H and(13)C NMR and DEPT) and 2D NMR (COSY, NOESY, HMQC, and HMBC) data. Chaetoglobosin U (1) exhibited cytotoxic activity against the human nasopharyngeal epidermoid tumor KB cell line with an IC(50) value of 16.0 microM, comparable to that (14.0 microM) of 5-fluorouracil co-assayed as a positive reference. The known analogues 2-5 were moderately active to the cell line, with IC(50) values of 34.0, 52.0, 48.0, and 40.0 microM, respectively.

• Authors: Gang Ding, Yong C Song, Jing R Chen, Chen Xu, Hui M Ge, Xiao T Wang, Ren X Tan
• Journal: Journal of natural products (J Nat Prod) Vol. 69 Issue 2 Pg. 302-4 (Feb 2006) ISSN: 0163-3864 [Print] United States
• PMID: 16499339 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Indole Alkaloids
• chaetoglobosins

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Chaetomium (chemistry)
• China
• Drug Screening Assays, Antitumor
• Humans
• Indole Alkaloids (chemistry, isolation & purification, pharmacology)
• KB Cells
• Molecular Structure