Immunohistochemical prognostic factors in resected colorectal lung metastases using tissue microarray analysis.

Abstract

AIMS:

Immunohistochemical prognostic factors of pulmonary metastatic colorectal cancer lesions have not been well investigated. The study was conducted to identify the immunohistochemical prognostic factors of metastasized colorectal cancer.

METHODS:

We immunohistochemically investigated the expression of insulin-like growth factor-1 receptor (IGF1-R), E-cadherin, beta-catenin, and p53 using a tissue microarray in the surgical specimens of 86 metastatic lesions.

RESULTS:

The univariate analysis revealed E-cadherin and membrane beta-catenin positive to be prognostic factors. IGF1-R and p53 were not significantly associated with the patient's survival. In multivariate analysis, the reduced expression of E-cadherin, aerogenous spread with floating cancer cell clusters and vascular invasion were independent prognostic factors.

CONCLUSIONS:

The reduced expression of E-cadherin in the pulmonary metastatic lesions was an independent predictor of poor survival after pulmonary metastasectomy.

• Authors: S Shiono, G Ishii, K Nagai, Y Murata, K Tsuta, J Nitadori, T Kodama, A Ochiai
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 32 Issue 3 Pg. 308-9 (Apr 2006) ISSN: 0748-7983 [Print] England
• PMID: 16459049 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biomarkers, Tumor
• Cadherins
• Tumor Suppressor Protein p53
• beta Catenin
• Receptor, IGF Type 1

Topics

• Biomarkers, Tumor (metabolism)
• Cadherins (metabolism)
• Carcinoma (metabolism, secondary, surgery)
• Colorectal Neoplasms (metabolism, pathology)
• Humans
• Immunohistochemistry
• Lung Neoplasms (metabolism, secondary, surgery)
• Pneumonectomy
• Prognosis
• Receptor, IGF Type 1 (metabolism)
• Retrospective Studies
• Tumor Suppressor Protein p53 (metabolism)
• beta Catenin (metabolism)