Clinical efficacy of an alpha1A/D-adrenoceptor blocker (naftopidil) on overactive bladder symptoms in patients with benign prostatic hyperplasia.

Abstract

AIM:

We evaluated the efficacy of an alpha1a/d blocker, naftopidil, on storage symptoms in patients with benign prostatic hyperplasia (BPH), using frequency/volume charts (FVC).

METHODS:

A total of 81 patients with BPH (52-91 years, mean age 69.0 years) were studied. The inclusion criteria were: (i) one or more episode(s) of urinary urgency/day; (ii) a score of eight or more points on the International Prostate Symptom Score (I-PSS); and (iii) three or more points in any of the scores for three items (frequency, nocturia, and urgency) of the I-PSS. The patients received 50-75 mg/day of naftopidil for 6 weeks. All the patients were examined for 2-day FVC before and after the administration of naftopidil. I-PSS, quality of life index, and uroflowmetry were also evaluated.

RESULTS:

Total I-PSS decreased from 19.1 to 10.5 points (P < 0.0001), with significant improvement of both storage and voiding symptom scores (P < 0.0001, both). The score for urgency decreased from 3.1 to 1.4 (P < 0.0001). Daytime and night-time frequency decreased from 9.3 to 8.0 (P < 0.0001) and from 2.7 to 2.0 (P = 0.0009), respectively. Mean volume/void increased from 174.0 to 188.6 mL (P = 0.0453). Nocturia decreased from 3.2 to 2.3 (P < 0.0001) in 40 patients who suffered from nocturia two times or more. Notably, significant improvement of nocturia was observed in the patients both with and without nocturnal polyuria (P = 0.0006 and 0.0135, respectively).

CONCLUSION:

The alpha1a/d blocker naftopidil improves not only voiding symptoms but also storage symptoms, and is effective for nocturia in patients with BPH regardless of the existence of nocturnal polyuria.

• Authors: Satoru Takahashi, Atsushi Tajima, Hisashi Matsushima, Takeshi Kawamura, Takashi Tominaga, Tadaichi Kitamura
• Journal: International journal of urology : official journal of the Japanese Urological Association (Int J Urol) Vol. 13 Issue 1 Pg. 15-20 (Jan 2006) ISSN: 0919-8172 [Print] Australia
• PMID: 16448426 (Publication Type: Comparative Study, Journal Article, Multicenter Study)

Chemical References

• Adrenergic alpha-Antagonists
• Naphthalenes
• Piperazines
• naftopidil

Topics

• Adrenergic alpha-Antagonists (therapeutic use)
• Aged
• Aged, 80 and over
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Naphthalenes (therapeutic use)
• Piperazines (therapeutic use)
• Prostatic Hyperplasia (complications, psychology)
• Quality of Life
• Retrospective Studies
• Treatment Outcome
• Urinary Incontinence (drug therapy, etiology, physiopathology)
• Urodynamics (drug effects)