Safety and efficacy of glycerol and amino acids in combination with lipid emulsion for peripheral parenteral nutrition support.
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| Abstract |
The safety and efficacy of administering lipid emulsion with ProcalAmine, a glycerol-based parenteral nutrition solution, for peripheral nutrition has not been previously studied. Thirty-four patients recovering from major trauma or surgery were studied while receiving a peripheral parenteral nutrition regimen of either ProcalAmine with 10% lipid emulsion (group 1) or ProcalAmine with 20% lipid emulsion (group 2) for up to 5 days postinjury. Daily dose was 45 mL/kg ProcalAmine, providing 1.35 g of amino acids/kg and 1.35 g of glycero/kg, and 500 mL/day lipid emulsion. The mean daily nitrogen balance was -0.3 g/day in group 1 and -4.1 g/day in group 2. There was no progressive accumulation of circulating glycerol, and urinary glycerol excretion was minimal (less than 0.2 g/day), indicating effective utilization of glycerol as an energy substrate. Our finding that nitrogen balance was better with 10% fat emulsion suggests a limitation in fat utilization in this setting. Both regimens were well tolerated; there were no adverse clinical reactions and no occurrences of phlebitis in either group.
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| Authors | K Waxman, A T Day, G P Stellin, G T Tominaga, A B Gazzaniga, R R Bradford |
| Journal | JPEN. Journal of parenteral and enteral nutrition (JPEN J Parenter Enteral Nutr) 1992 Jul-Aug Vol. 16 Issue 4 Pg. 374-8 ISSN: 0148-6071 [Print] United States |
| PMID | 1640637 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
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