Discorhabdin W, the first dimeric discorhabdin.

Abstract

Discorhabdin W (1), isolated from a New Zealand Latrunculia sp. sponge, is a symmetrical dimer with potent in vitro activity against the P388 murine leukemia cell line. The structure and stereochemistry were assigned by using 1D- and 2D-NMR experiments and mass spectrometry. Discorhabdins B (2), D (3), G/I (4), and L (5) were also isolated from the same sponge.

• Authors: Gerhard Lang, André Pinkert, John W Blunt, Murray H G Munro
• Journal: Journal of natural products (J Nat Prod) Vol. 68 Issue 12 Pg. 1796-8 (Dec 2005) ISSN: 0163-3864 [Print] United States
• PMID: 16378380 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Quinones
• Spiro Compounds
• Thiazepines
• discorhabdin W

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Leukemia P388
• Molecular Structure
• New Zealand
• Nuclear Magnetic Resonance, Biomolecular
• Porifera (chemistry)
• Quinones (chemistry, isolation & purification, pharmacology)
• Spiro Compounds (chemistry, isolation & purification, pharmacology)
• Thiazepines (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured