[Statins for the prevention of colorectal carcinoma: not yet recommended].

Abstract

Statins are widely prescribed as lipid-lowering agents in the primary and secondary prevention of cardiovascular disease. They are increasingly associated with potential chemopreventive effects with respect to cancer. A recent case-control study reported a 47% relative reduction in the risk of colorectal cancer associated with statin use after adjustment for other known risk factors. There is evidence of an inhibitory effect of statins on colorectal carcinogenesis from in vitro studies, animal experiments, and observational and epidemiological reports in humans. Although statins seem promising as chemopreventive agents, it is still too early to recommend their use against colorectal cancer outside the context of clinical trials.

• Authors: J J Koornstra, J H Kleibeuker
• Journal: Nederlands tijdschrift voor geneeskunde (Ned Tijdschr Geneeskd) Vol. 149 Issue 43 Pg. 2388-91 (Oct 22 2005) ISSN: 0028-2162 [Print] Netherlands
• Vernacular Title: Statinen ter preventie van colorectaal carcinoom vooralsnog niet aanbevolen.
• PMID: 16277127 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hydroxymethylglutaryl-CoA Reductase Inhibitors

Topics

• Case-Control Studies
• Colorectal Neoplasms (prevention & control)
• Evidence-Based Medicine
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Risk Factors