Abstract | OBJECTIVE: METHODS: All patients undergoing CEA from 1994 to 2004 at a large academic medical center were retrospectively reviewed. The independent association of statin use and perioperative morbidity was assessed via multivariate logistic regression analysis. RESULTS: CEA was performed by 13 surgeons on 1566 patients (987 men and 579 women; mean age, 72 +/- 10 years), including 1440 (92%) isolated and 126 (8%) combined CEA/ coronary artery bypass grafting procedures. The indication for CEA was symptomatic disease in 660 (42%) cases. Six hundred fifty-seven (42%) patients received a statin medication for at least 1 week before surgery. Statin use was associated with a reduction in perioperative strokes (1.2% vs 4.5%; P < .01), transient ischemic attacks (1.5% vs 3.6%; P < .01), all-cause mortality (0.3% vs 2.1%; P < .01), and median (interquartile range) length of hospitalization (2 days [2-5 days] vs 3 days [2-7 days]; P < .05). Adjusting for all demographics and comorbidities in multivariate analysis, statin use independently reduced the odds of stroke threefold (odds ratio [95% confidence interval], 0.35 [0.15-0.85]; P < .05) and death fivefold (odds ratio [95% confidence interval], 0.20 [0.04-0.99]; P < .05). CONCLUSIONS: These data suggest that perioperative statin use may reduce the incidence of cerebrovascular events and mortality among patients undergoing CEA.
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Authors | Matthew J McGirt, Bruce A Perler, Benjamin S Brooke, Graeme F Woodworth, Alexander Coon, Shamik Jain, Donald Buck, Glen S Roseborough, Rafael J Tamargo, Jennifer Heller, Julie A Freischlag, George M Williams |
Journal | Journal of vascular surgery
(J Vasc Surg)
Vol. 42
Issue 5
Pg. 829-36; discussion 836-7
(Nov 2005)
ISSN: 0741-5214 [Print] United States |
PMID | 16275430
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Topics |
- Aged
- Carotid Stenosis
(diagnosis, surgery)
- Endarterectomy, Carotid
(adverse effects)
- Female
- Follow-Up Studies
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Male
- Multivariate Analysis
- Perioperative Care
- Postoperative Complications
(mortality, prevention & control)
- Retrospective Studies
- Risk Factors
- Stroke
(etiology, mortality, prevention & control)
- Survival Rate
- Treatment Outcome
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