8-(1-Naphthalen-2-yl-vinyl)-6,7,10-trioxaspiro (4.5) decane, a new 1,2,4-trioxane effective against rodent and simian malaria.

Abstract

A new series of 8-(1-aryl-vinyl)-6,7,10-trioxaspiro [4.5] decanes 7a-e and 3-(1-aryl-vinyl)-l,2,5-trioxaspiro [5.5] undecanes 8a-e have been prepared and screened against multi-drug resistant Plasmodium yoelii in mice. 8-(1-Naphthalen-2-yl-vinyl)-6,7,10-trioxaspiro [4.5] decane 7b, the most active trioxane of the series, has also shown promising activity against Plasmodium cynomolgi in rhesus monkeys.

• Authors: Chandan Singh, Rani Kanchan, Divya Srivastava, Sunil K Puri
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 16 Issue 3 Pg. 584-6 (Feb 2006) ISSN: 0960-894X [Print] England
• PMID: 16275088 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 1,2,4-trioxane
• 8-(1-naphthalen-2-yl-vinyl)-6,7,10-trioxaspiro (4.5) decane
• Antimalarials
• Heterocyclic Compounds
• Naphthalenes
• Spiro Compounds

Topics

• Animals
• Antimalarials (pharmacology)
• Dose-Response Relationship, Drug
• Drug Resistance, Multiple (drug effects)
• Haplorhini
• Heterocyclic Compounds (chemical synthesis, pharmacology, therapeutic use)
• Malaria (drug therapy)
• Mice
• Naphthalenes (chemical synthesis, pharmacology)
• Plasmodium cynomolgi (drug effects)
• Plasmodium yoelii (drug effects)
• Spiro Compounds (chemical synthesis, pharmacology)