Abstract | BACKGROUND:
Dumping syndrome is a serious complication occurring in 10% of patients after gastric surgery. Dumping symptoms are effectively reduced by subcutaneous application of the somatostatin analogue octreotide, but side-effects limit its use. AIM: To evaluate the efficacy of depot long-acting release octreotide ( Sandostatin-LAR) vs. octreotide subcutaneous on dumping symptoms, quality of life and side-effects. METHODS: Twelve patients (five females, age 58 +/- 3 years) with severe dumping symptoms, requiring daily use of octreotide subcutaneous, were included in an open study and changed from octreotide subcutaneous after a 2 weeks washout to Sandostatin-LAR 10 mg i.m., every 4 weeks for 6 months. Symptoms (diary), body weight, fat excretion, food intake and Gastrointestinal Specific Quality of Life Index were evaluated. RESULTS: Gastrointestinal Specific Quality of Life Index increased significantly (P < 0.05) during Sandostatin-LAR treatment (88 +/- 4) compared with octreotide (74 +/- 4) and washout (75 +/- 6). During Sandostatin-LAR treatment, abdominal symptom score was lower compared with octreotide and washout, but not significantly. During Sandostatin-LAR treatment, body weight increased (66 +/- 4 to 70 +/- 3 kg; P = 0.19). CONCLUSIONS:
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Authors | C Penning, J Vecht, A A M Masclee |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 22
Issue 10
Pg. 963-9
(Nov 15 2005)
ISSN: 0269-2813 [Print] England |
PMID | 16268971
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Delayed-Action Preparations
- Gastrointestinal Agents
- Octreotide
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Topics |
- Body Weight
- Chronic Disease
- Delayed-Action Preparations
- Dumping Syndrome
(drug therapy)
- Female
- Gastrointestinal Agents
(administration & dosage, adverse effects)
- Humans
- Injections, Subcutaneous
- Male
- Middle Aged
- Octreotide
(administration & dosage, adverse effects)
- Quality of Life
- Treatment Outcome
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