Comparative acceptability of combined and progestin-only injectable contraceptives in Kenya.

Abstract

OBJECTIVE:

We compared 12-month continuation rates, menstrual bleeding patterns and other aspects of acceptability between users of Cyclofem and users of Depo-Provera.

METHODS:

The life-table method was used to calculate quarterly continuation rates. In all, 360 Kenyan women were randomly assigned to one of the two contraceptives. User-satisfaction questionnaires were administered at 6 and 12 months or at discontinuation, whichever occurred first.

RESULTS:

The 1-year continuation rate was 75.4% for Depo-Provera users versus 56.5% for Cyclofem users (p<.001). Main reasons for discontinuation included difficulty making clinic visits (45.1% for Cyclofem vs. 40% for Depo-Provera), menstrual changes (14.1% vs. 12.5%) and nonmenstrual problems (15.5% vs. 12.5%). None of the Depo-Provera users and 8.5% of the Cyclofem users claimed frequency of visits as the main reason for discontinuation. In all, 70.6% of the Depo-Provera users were amenorrheic after 12 months, as were 20.8% of the Cyclofem users.

CONCLUSIONS:

The 1-year continuation rate was higher for Depo-Provera than for Cyclofem. There was no important difference in discontinuation rates because of menstrual problems; the difference mainly reflected the frequency of visits required.

• Authors: Joseph K Ruminjo, Christine B Sekadde-Kigondu, Joseph G Karanja, Roberto Rivera, Marlina Nasution, Tara Nutley
• Journal: Contraception (Contraception) Vol. 72 Issue 2 Pg. 138-45 (Aug 2005) ISSN: 0010-7824 [Print] United States
• PMID: 16022854 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Contraceptive Agents, Female
• Contraceptives, Oral, Combined
• Drug Combinations
• Estradiol
• CycloProvera
• Medroxyprogesterone Acetate

Topics

• Adult
• Contraceptive Agents, Female (administration & dosage)
• Contraceptives, Oral, Combined (administration & dosage)
• Drug Combinations
• Estradiol (administration & dosage, analogs & derivatives)
• Female
• Follow-Up Studies
• Humans
• Medroxyprogesterone Acetate (administration & dosage)
• Menstruation Disturbances (chemically induced)
• Patient Satisfaction
• Random Allocation
• Surveys and Questionnaires