[Correlation between platelet count and CA-125 in ovarian cancer].

Abstract

OBJECTIVE:

To determine whether a correlation between platelet count and CA-125 exists, and to compare the mean levels of CA-125 in groups with normal and elevated platelet counts.

DESIGN:

A retrospective analysis of the medical records concerning to 31 ovarian cancer inpatients, treated 1998-2002 with primary surgery and subsequent platinum-based chemotherapy at the Division of Gynecology, Department of Perinatology and Gynecology, University Medical School Poznań.

MATERIALS AND METHODS:

137 serum and whole blood samples collected from 31 ovarian cancer patients during their consecutive hospital stays.

RESULTS:

There was a positive, moderate (r = 0.49) and highly significant (p < 0.0000001) correlation between platelet count and CA-125 levels. Thrombocytosis occurred in 45% patients before treatment, and in none when the 6th course of chemotherapy was given. In the thrombocytosis group, an average CA-125 level (913.5 U/ml) was significantly higher (p < 0.00001) then in the group with normal platelet count (103.7 U/ml).

CONCLUSIONS:

Platelet count and CA-125 levels do correlate in blood samples taken from ovarian cancer patients at the same time.

• Authors: Zbigniew Friebe, Rafał Watrowski, Maciej Bembnista, Anita Rokowska, Joanna Włosiińska, Małgorzata Dembińska
• Journal: Ginekologia polska (Ginekol Pol) Vol. 76 Issue 3 Pg. 187-94 (Mar 2005) ISSN: 0017-0011 [Print] Poland
• Vernacular Title: Znaczenie kliniczne poziomu płytek krwi w raku jajnika.
• PMID: 16018136 (Publication Type: English Abstract, Journal Article)

Chemical References

• CA-125 Antigen

Topics

• Adult
• Aged
• CA-125 Antigen (blood)
• Female
• Humans
• Medical Records
• Middle Aged
• Neoplasm Staging
• Ovarian Neoplasms (blood, complications, drug therapy, immunology)
• Platelet Count
• Poland
• Retrospective Studies
• Risk Factors
• Thrombocytosis (drug therapy, immunology)